NexGard is a widely used oral medication for dogs that provides effective flea and tick control. Its mechanism of action involves a unique active ingredient called afoxolaner, which selectively targets and kills parasites, ensuring the wellbeing of our furry friends.

NexGard belongs to the class of drugs known as isoxazolines, which are characterized by their ability to disrupt the nervous system of parasites. Once ingested by the dog, afoxolaner is absorbed into its bloodstream, eventually reaching the target parasites. This innovative compound works by targeting a specific protein receptor called gamma-aminobutyric acid (GABA) receptor and glutamate receptor, both of which are essential for normal nerve cell functioning in parasites.

GABA is a neurotransmitter that acts as an inhibitory signal in the central nervous system. It plays a vital role in regulating nerve impulses and maintaining balance within the nervous system. By selectively binding to the GABA receptors of parasites, afoxolaner interferes with the normal transmission of neuronal signals, causing excessive activation and hyperexcitation of the parasite’s nervous system.

Glutamate is another neurotransmitter that acts as an excitatory signal in the central nervous system. It is responsible for transmitting signals between nerve cells, promoting their communication. Afoxolaner also binds to the glutamate receptor of parasites, hindering the normal flow of excitatory signals. This disrupts the parasite’s ability to coordinate its bodily functions, leading to its eventual paralysis and death.

Both GABA and glutamate receptors are present in insects and arachnids, including fleas and ticks. By selectively targeting these receptors, afoxolaner ensures that NexGard effectively eliminates these parasites without impacting the dog’s own nervous system.

One of the advantages of NexGard is its rapid onset of action. Once the dog ingests the medication, afoxolaner quickly reaches peak plasma concentration within hours. This quick absorption and distribution throughout the body allow for a swift and effective response against fleas and ticks.

Furthermore, NexGard offers protection for up to 30 days. It continues to kill parasites and prevents new infestations, giving pet owners peace of mind. By regularly administering NexGard, dog owners can ensure their pets are protected from the discomfort and potential diseases spread by fleas and ticks.

It’s important to note that NexGard is FDA-approved and has undergone rigorous testing to ensure its safety and efficacy. However, as with any medication, some dogs may experience mild adverse effects, such as gastrointestinal disturbances or neurological signs. It is always recommended to consult with a veterinarian before starting any new medication for your pet.

In conclusion, NexGard provides an effective and convenient solution for flea and tick control in dogs. Its mechanism of action, through the active ingredient afoxolaner, selectively targets and disrupts the nervous system of parasites, leading to their paralysis and death. With its rapid onset of action and long-lasting protection, NexGard is a trusted and reliable option for pet owners worldwide, ensuring their furry companions are free from these pesky parasites.

Quest'articolo è stato scritto a titolo esclusivamente informativo e di divulgazione. Per esso non è possibile garantire che sia esente da errori o inesattezze, per cui l’amministratore di questo Sito non assume alcuna responsabilità come indicato nelle note legali pubblicate in Termini e Condizioni
Quanto è stato utile questo articolo?
0Vota per primo questo articolo!